The 1~20 genetic variants used by StoreGene add up to a powerful Genetic Profile Test for heart disease risk.  From the published data and our own results, we can accurately predict the frequency of the number of individuals in the UK white population carrying different numbers of risk variants. Figure 1 shows how many individuals with different numbers of the combined risk alleles we expect. The most common group have 5 risk alleles, with 10% having only 3 and 6% having 2 or less, while 12% have 7 risk alleles and 10% have 8 or more.  The consequence of this on predicted risk is shown in Figure 2.  We have set a relative risk of 1 as occurring in those individuals in the commonest group (5 risk alleles) and compared to these, those with 3 risk alleles have a roughly 20% lower and those with 2 or fewer have 50% reduction.  By contrast, those with 9 or more have a risk approaching 2. So we can predict from this that roughly 10% of the population will be at a clinically important higher risk and roughly 10% will be at lower risk based on the combined information from these 17 variants. How the test will work? © StoreGene, 2011